Telomeres and G-quadruplexes
Targeting G-quadruplexes with CRISPR
DNA-based Liquid Crystals
The capability of chemically synthesizing DNA provides extreme control on designing and generating molecular structures with different sizes, shapes and geometries. Such DNA molecules form different phases and attain different characteristics and long range structures when they are condensed to high concentrations. Liquid crystal phases, where materials demonstrate both crystal-like and liquid-like characteristics, are some of the fundamentally important phases formed by DNA molecules.
In our approach, DNA molecules that have both rigid and flexible regions, such as two double stranded DNA molecules that are connected by a single strand, are particularly potent at demonstrating different liquid crystal phases at different concentrations. These phases are typically studied by small angle or wide angle X-ray scattering and polarized optical microscopy.